Ubiquitously Expressed Transcript (UXT)

Protein UXT is a novel protein which is highly conserved in mouse. It interacts with the N-terminus of the androgen receptor and plays a role in facilitating receptor-induced transcriptional activation. It is also likely to be involved in tumorigenesis as it is abundantly expressed in tumor tissues. This gene is part of a gene cluster on chromosome Xp11.23. Alternative splicing results in 2 transcript variants encoding different isoforms.Based on a consensus sequence from 14 different ESTs with significant sequence similarity to UXT, they determined that UXT encodes a 157-amino acid protein with 3 potential phosphorylation sites. a protein that shares 90% identity with human UXT, with all 3 potential phosphorylation sites conserved, indicating that these sites are of functional importance.