Unc-80 Homolog (UNC80)

Unc80 was required for proper localization or stabilization of axonal NCA ion channel components, which are homologous to the vertebrate NALCN channel.The activation of substance P through its G protein-coupled receptor TACR1 occurs by means of a unique mechanism: it does not require G protein activation but is dependent on Src family kinases.The deduced protein contains 1,341 amino acids. RT-PCR ELISA detected C2ORF21 expression in adult and fetal brain and in all specific adult brain regions examined. Very low expression was detected in testis and pancreas, and no expression was detected in other adult and fetal tissues examined.The deduced protein contains 3,184 amino acids. Fluorescence-tagged Unc80 was highly expressed throughout the worm nervous system, as well as in other tissues.