V-Mos Moloney Murine Sarcoma Viral Oncogene Homolog (MOS)

MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1) . The Moloney murine sarcoma virus (MSV) is a representative of a class of replication-defective retroviruses that transform fibroblasts in culture and induce sarcomas in vivo. It arose by recombination between the Moloney murine leukemia virus and a sequence derived from mouse cells. The mouse cell-derived segment of MSV, termed v-mos, is required for induction and maintenance of viral transformation, and the normal mouse analog of v-mos has been cloned. The deduced 346-amino acid human protein shares significant homology with the mouse protein, with regions of lowest homology near the N and C termini and in a central 11-amino acid stretch.