Zinc Finger And BTB Domain Containing Protein 7C (ZBTB7C)

ZBTB7C May be a tumor suppressor gene.Contains 1 BTB (POZ) domain.Contains 4 C2H2-type zinc fingers.Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain. They have also found use in protein engineering due to their modularity and have prospects as components of tools for use in therapeutic gene modulation and zinc finger nucleases. Zinc finger protein consists of anti-parallel hairpin motif. It consists of 2 beta strands, one alpha helix and a hairpin structure.