Chromodomain Protein, Y-Linked 2 (CDY2)

Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. CDY2A is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes.The predicted 541-amino acid CDY2 protein is 98% identical to CDY1. The CDY2 gene does not contain introns. The authors stated that there might be multiple CDY1 and CDY2 genes.