Motile Sperm Domain Containing Protein 1 (MOSPD1)

By database searching with the mouse Mospd3 sequence as query, Pall et al. (2004) identified mouse and human MOSPD1. Both deduced proteins have 213 amino acids and contain a major sperm protein (MSP) domain and 2 transmembrane domains.MOSPD1 belongs to the transmembrane MSP-containing protein family. Its role in mammals is largely unknown but it is thought to be involved in the formation of protein-protein networks. The sequence/structure comparison of VAP27 with the crystal structure of AsMSP1 from Ascaris suum, using molecular modeling with the threading method, suggested that the N-terminus of VAP27 does possess a MSP-like domain that might participate in the formation of a protein-protein network.