Pregnancy Specific Beta-1-Glycoprotein 6 (PSG6)

The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily.PSG10, which had been thought to be a novel gene, is in fact an allelic variant of PSG6 that differs by 10 bp in the coding region.The PSG genes are tandemly oriented in a 5-prime to 3-prime direction from telomere to centromere. The CEA subgroup gene CGM11 is located at the telomeric end of the PSG gene cluster, and 6 genes belonging to a third CEA family subgroup, namely CGM13 through CGM18 (later found to be pseudogenes), are interspersed among the PSG genes.