Pregnancy Specific Beta-1-Glycoprotein 9 (PSG9)

The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. The PSG genes are tandemly oriented in a 5-prime to 3-prime direction from telomere to centromere. The CEA subgroup gene CGM11 is located at the telomeric end of the PSG gene cluster, and 6 genes belonging to a third CEA family subgroup, namely CGM13 through CGM18, are interspersed among the PSG genes.Based on this nomenclature, the CEA family is composed of the PSG subfamily, the CEACAM subfamily, and the CEACAM pseudogene (CEACAMP) subfamily. PSG11, PSG12, and PSG13 were renamed PSG9, PSG10, and PSG11, respectively.