Sperm Associated Antigen 5 (SPAG5)

SPAG5 encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.Cytoplasm. Spindle. In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed. Necessary for normal spindle formation during mitosis.Homodimer, with a globular head domain and a long stalk. Homo-oligomer; the globular head domains associate, resulting in aster-like structures. Binds to microtubules in the mitotic spindle.