2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing Protein 2 (OGFOD2)

OGFOD2 Belongs to the OGFOD2 family. Contains 1 Fe2OG dioxygenase domain. Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.