A Kinase Anchor Protein 6 (AKAP6)

AKAP6 is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.The AKAP6 protein contains 655 amino acids. Helical wheel analysis revealed the presence of an amphipathic helix similar to that in other AKAPs. expression of a single transcript of 8 kb, with highest expression in cardiac and skeletal muscle. Expression was also present in certain areas of the brain, including cerebellum, basal ganglia, hippocampus, frontal cortex, and motor cortex. By multiple rounds of 5-prime RACE, they obtained a full-length cDNA encoding AKAP6, which they called mAKAP (muscle AKAP).