A Kinase Anchor Protein 7 (AKAP7)

A-kinase anchor protein 7 isoform gamma is a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments.AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described. Additional variants exist, but their full-length natures have not been determined.AKAPs act as targeting devices that assemble signaling elements on a scaffold that itself targets to microdomains in cells.