APC Membrane Recruitment Protein 1 (AMER1)

The mouse WTX expression was relatively high in neonatal brain and kidney and declined substantially in mature organs. Lung and spleen also expressed WTX, but with a less notable developmental profile. Temporal patterns of WTX and WT1 expression within the kidney were virtually identical, consistent with a wave of differentiation that is ongoing at birth and completed by postnatal week 3. As assessed by RNA in situ hybridization, WT1 and WTX display a high, but not complete, degree of overlap in expression in the kidney. Similar to WT1, WTX is expressed in the condensing metanephric mesenchyme and in early epithelial structures that are precursors to glomeruli. Thus both genes are present in the pluripotent cells that are the presumed precursors of Wilms tumor.