AT-Rich Interactive Domain Containing Protein 3C (ARID3C)

ARID3C is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.ARID3A, is an activator of the immunoglobulin heavy chain locus. Bright interacts with sumoylation E2 (UBC9) and E3 (PIAS1) components and undergoes modification by SUMO-1. Bright has been shown to immortalize mouse embryonic fibroblasts and induce malignant transformation when co-expressed with oncogenic Ras. A genomic locus that encodes a gene paralogous to Bright has been identified as Brightlike/ARID3C.