AT-Rich Interactive Domain Containing Protein 4A (ARID4A)

ARID4A encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.The deduced 1,257-amino acid protein has a calculated molecular mass of 142.6 kD. The N-terminal region of RBP1 contains a cluster of charged amino acids, and the C-terminal region contains the LxCxE RB-binding motif.