ATP Binding Cassette Transporter F3 (ABCF3)

ATP-binding cassette sub-family F member 3 contains two ABC transporter domains. Some members of the ABC transporter superfamily play a role in transport of physiologic substrates and are responsible for chemotherapy drug exclusion. ABCF3 lacks transmembrane domains and is probably not involved in transport. ABC transporters belong to the ATP-Binding Cassette superfamily, which uses the hydrolysis of ATP to translocate a variety of compounds across biological membranes. ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These regions can be found on the same protein or on two different ones. Most ABC transporters function as a dimer and therefore are constituted of four domains, two ABC modules and two TMDs.