ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D1 (ATP6V0D1)

ATP6V0D1 encodes a component of vacuolar ATPase, a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. This encoded protein is known as the D subunit and is found ubiquitously. The protein has a calculated molecular mass of about 32 kD and shows 99% sequence homology with bovine subunit D. Northern blot analysis revealed ubiquitous and comparable expression of a 1.8-kb transcript.ATP6V0D1 gene consists of 8 exons spanning approximately 19 kb. They found that the gene is located immediately adjacent to the HSD11B2 gene and is oriented in the opposite direction, with the 3-prime ends of the 2 genes only 0.5 kb apart. Stimulation of human kidney cortical collecting duct cells or choriocarcinoma cells indicated that their expression is regulated independently.