AVL9 Homolog (AVL9)

Nagase et al. (1996) cloned partial AVL9, which they designated KIAA0241. Northern blot analysis detected low expression in brain, lung, testis, liver, heart, skeletal muscle, kidney, pancreas, spleen, ovary, small intestine, colon, and peripheral blood leukocytes.Harsay and Schekman (2007) identified S. cerevisiae Avl9 as a protein whose absence confers a lethal phenotype in a yeast Vps1/Apl2 double-null mutant.By subcellular fractionation and other studies, Harsay and Schekman (2007) showed that loss of S. cerevisiae Avl9p caused a general transport or sorting defect at the Golgi characterized by disruption of secretory vesicle generation and defects in actin polarization/polarized growth. Overexpression of Avl9p resulted in vesicle accumulation and a post-Golgi secretory defect.