Actin Filament Associated Protein 1 Like Protein 1 (AFAP1L1)

Two other proteins (AFAP and AFAP1L1) were found to have a significant similarity to XB130 and were compared in detail. After an analysis of these three proteins, it was proposed that they are members of a novel protein family, termed the “AFAP family of signal adaptor proteins”. The objective of the present study was to perform a genome wide search of proteins which are similar to XB130 and AFAP, and to gain systemic knowledge of these proteins for their expression, distribution, and potential functions. Sequence alignment showed that all three of these proteins have approximately 25% identical amino acids and share many conserved functional domains including N-terminal SH2/SH3 binding domains, two consecutive pleckstrin homology domains; however differ in their unique C-terminal regions.