Activating Transcription Factor 1 (ATF1)

MMSP is a rare and aggressive tumor that mainly develops in tendons and aponeuroses of patients between 15 and 35 years of age, and which may also be derived from neuroectoderm (Chung and Enzinger, 1983; Epstein et al., 1984). Zucman et al. (1993) demonstrated that the hybrid transcripts in the t(12;22) cases encoded a chimeric protein consisting of the N-terminal domain of EWS (133450) linked to the bZIP domain of ATF1.Zucman et al. (1993) showed by fluorescence in situ hybridization that the ATF1 gene maps to 12q13. Bicolor FISH on interphase nuclei from an MMSP cell line showed that the EWS locus was split and that the proximal part of EWS was juxtaposed to the ATF1 locus.