Acyl Coenzyme A Binding Domain Containing Protein 5 (ACBD5)

ACBD5 maps on chromosome 10, at 10p12.1 according to Entrez Gene. ACBD5 is expressed at high level, 1.9 times the average gene in this release.ACBD5contains 20 different gt-ag introns. Transcription produces 13 alternatively spliced mRNAs. There are 3 probable alternative promotors and 8 validated alternative polyadenylation sites. The mRNAs appear to differ by presence or absence of 3 cassette exons, overlapping exons with different boundaries, alternative splicing or retention of 2 introns. Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.