Adaptor Related Protein Complex 1 Mu 2 (AP1m2)

AP1M2 is a member of the medium chain family of the clathrin-associated adaptor complex AP1. It is expressed exclusively in epithelial cells and may mediate basolateral sorting of membrane proteins in polarized epithelial cells.The deduced 423-amino acid protein has a calculated molecular mass of 48 kD and shares 97% sequence identity with the mouse Ap1m2 protein. expression restricted to placenta, lung, kidney, pancreas, prostate, testis, small intestine, and colon. In situ hybridization on mouse embryos revealed highest levels of Ap1m2 mRNA within intestinal mucosa of the gastrointestinal tract, acinar cells of the pancreas, epithelial cells of hair follicles, and secretory cells (ameloblasts and odontoblasts) in developing teeth. In vivo transcription/translation resulted in a protein with an apparent molecular mass of about 47 kD.