Adenine Nucleotide Translocator 3, Mitochondrial (ANT3)

SLC25A6 is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. The physical location of the ANT3 gene was determined by pulsed field mapping. From the location of a CpG island, they determined the orientation of the gene to be from centromere toward the telomere. It is probably directly adjacent to CSF2RA. All pseudogenes of the ANT gene family seem to lack introns.