AlkB, Alkylation Repair Homolog 7 (ALKBH7)

By database analysis to identify sequences similar to ABH genes, followed by PCR of a testis cDNA library, Tsujikawa et al. (2007) cloned ALKBH7, which they called ABH7. The deduced 221-amino acid protein has a C-terminal AlkB homology domain that is predicted to function as a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. Quantitative real-time PCR detected variable ABH7 expression in all 16 tissues examined, with highest expression in pancreas, followed by spleen, prostate, ovary, and placenta. Fluorescence-tagged ABH7 was expressed in both the cytoplasm and nucleus of transfected HeLa cells.Hartz (2010) mapped the ALKBH7 gene to chromosome 19p13.3 based on an alignment of the ALKBH7 sequence with the genomic sequence (GRCh37).