Angiopoietin Like Protein 5 (ANGPTL5)

The angiopoietins are a family of growth factors specific for vascular endothelium. During large-scale DNA sequencing of a human fetal brain cDNA library, Zeng et al. (2003) cloned a novel human angiopoietin-like cDNA and termed it angiopoietin-like-5 (ANGPTL5). Like other members of the angiopoietin family, the deduced 388-amino acid ANGPTL5 protein has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. RT-PCR analysis detected expression of ANGPTL5 in all tissues tested, but mainly in adult human heart.Zeng et al. (2003) determined that the ANGPTL5 gene contains 8 exons and spans approximately 17.3 kb.By genomic sequence analysis, Zeng et al. (2003) mapped the ANGPTL5 gene to chromosome 11q22.