Angiotonin Transactivated Protein 1 (ATP1)

ATP1 Belongs to the UPF0405 family.Renal hypertension is believed to be caused by an alteration in a vasopressor system having its origin in the kidneys. Renin, liberated from the kidneys, reacts with a globulin fraction from the blood to produce a pressor substance, angiotonin. Rcnin itself is not vasopressor nor do any of the blood globulins exhibit pressor activity. Angiotonin is physiologically highly active but can be inactivated by angiotonase,an enzyme present in the kidneys and other tissue. The formation and destruction of angiotonin are possibly balanced in normal animals and, when the balance is disturbed, hypo- or hypertension may occur. Although the reactions are intimately connected, they can be studied separately.It has been suggested that the reaction is enzymatic, renin acting as the enzyme and renin activator as the substrate, but rigorous proof is lacking.