Anion Exchange Protein 2 (AE2)

Demuth et al. (1986) isolated a cDNA clone, designated pHKB3, encoding a human erythrocyte surface protein band 3-like gene product. Peptide mapping shows substantial sequence homology between the erythrocyte band 3 protein and a band 3-like protein found in leukocytes. Palumbo et al. (1986) described the partial sequence of a 2.7-kb human cDNA clone encoding a band 3-related protein in nonerythroid cells. Comparison of the predicted amino acid sequence for this cDNA with the amino acid sequences of mouse and human erythroid band 3 proteins confirmed that the human clone is related to but distinct from erythroid band 3. Palumbo et al. (1986) symbolized the gene as HKB3, in part after the name of the human cell line studied.in the rat, AE2 is particularly abundant in the stomach and portions of the gastrointestinal tract.