Ankyrin Repeat And Zinc Finger Domain Containing Protein 1 (ANKZF1)

Ankzf1 is expressed specifically in the ventricular zone as well as the cortical plate towards the caudal region of the cerebral cortex. Ankzf1 is expressed in the primordial plexiform and the ventricular zone layers of the telencephalon at E11.5. By E13.5, Ankzf1 is weakly expressed in the ventricular zone, but is highly expressed in the cortical plate. From E17.5 to P1.5, the expression of Ankzf1 is maintained in the cerebral cortex. In the adult, Ankzf1 expression is obvious in the piriform cortex, hippocampus and cerebellum. Interaction studies of several VIM proteins reveal that these cofactors display dramatically different affinities, ranging from high affinity interactions characterized by dissociation constants of ∼20 nm for gp78 and ANKZF1 to only weak binding in our assays.