Anosmin 1 (ADMLX)

KAL protein is N-glycosylated, secreted in the cell culture medium, and localized at the cell surface.Several lines of evidence indicated that heparan-sulfate chains of proteoglycan(s) are involved in the binding of the KAL protein to the cell membrane.The protein is synthesized by definite neuronal cell populations, including Purkinje cells in the cerebellum, mitral cells in the olfactory bulbs, and several subpopulations in the optic tectum, and the striatum. The protein, with an approximate molecular mass of 100 kD, was named anosmin-1 by the authors in reference to the deficiency of the sense of smell that characterizes Kallmann disease. Anosmin-1 was thought to be an extracellular matrix component. Since heparin treatment of cell membrane fractions from cerebellum and tectum resulted in the release of the protein,