Armadillo Repeat Containing Protein 12 (ARMC12)

C6orf81 Contains 3 ARM repeats. The three dimensional structure of the ARM repeats from both b-catenin and importin-alpha reveal that individual ARM repeats are composed of three alpha helices. A short helix is followed by two longer helices which pack against each other in an antiparallel fashion. The first helix is perpendicular to both the second and third helix. Contiguous ARM repeats organize to form a right handed super helix of alpha helices. The tight and repetitive packing of the helices creates a contiguous hydrophobic core that extends through the structure. Despite a high degree of variability at the amino acid level, the three dimensional structures of ARM repeats are highly conserved. The long groove in the super helix formed by the tandemly repeated ARM sequences appears to function in binding with target proteins.