Autophagy Related Protein 16 Like Protein 2 (ATG16L2)

WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking.Atg16L2 (ATG16 autophagy related 16-like 2), also known as WDR80 (WD repeat-containing protein 80), is a 619 amino acid protein that localizes to the cytoplasm and contains seven WD repeats. Expressed as three alternatively spliced isoforms, Atg16L2 belongs to the WD repeat Atg16 family and is thought to play a role in autophagy.