BolA Like Protein 3 (BOLA3)

By searching databases for sequences similar to E. coli BolA, followed by RT-PCR of total brain RNA, Zhou et al. (2008) cloned human BOLA1, BOLA2, and BOLA3. The deduced 107-amino acid BOLA3 protein has an apparent N-terminal signal peptide, followed by a BolA domain containing a helix-turn-helix motif near its C terminus. RT-PCR analysis detected variable expression of 2 BOLA3 variants in all normal human tissues examined. BOLA3 was secreted into the culture medium of transfected COS-7 cells.Zhou et al. (2008) determined that the BOLA3 gene contains 4 coding exons.Hartz (2009) mapped the BOLA3 gene to chromosome 2p13.1 based on an alignment of the BOLA3 sequence with the genomic sequence (GRCh37).