Brain Abundant, Membrane Attached Signal Protein 1 (BASP1)

BASP1 encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation.The human protein, which is myristoylated at its N terminus, is 80% and 70% similar to the bovine and rat proteins, respectively. SDS-PAGE and Western blot analysis determined that BASP1 is expressed as a nearly 23-kD protein. Sequence analysis indicated the presence of several transient phosphorylation sites as well as PEST sequences, which are typical of proteins with high turnover rates, such as GAP43 and MARCKS (MACS).