Bruno Like 4, RNA Binding Protein (BRUNOL4)

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.In addition to the 3 RRMs, the deduced 486-amino acid CELF4 protein contains multiple potential phosphorylation sites and a consensus nuclear localization signal near the C terminus. Western blot analysis of adult mouse tissues detected multiple CELF4 isoforms that were expressed predominantly in skeletal muscle and brain.