C1GALT1 Specific Chaperone 1 (C1GALT1C1)

C1GALT1C1 encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. C1GALT1C1 encodes a deduced 318-amino acid type II membrane protein containing a 10-residue cytoplasmic tail, a transmembrane domain, and a 288-residue catalytic domain. C1GALT1C1 and C1GALT1 share conservation of 7 cysteine residues in the catalytic domain, although overall amino acid homology within this domain is only 26%.