CCR4 NOT Transcription Complex Subunit 4 (CNOT4)

CNOT4 is a subunit of the multifunctional CCR4)/NOT complex implicated in transcriptional regulation and RNA deadenylation. CNOT4 has both positive and negative roles in transcriptional regulation and a positive role in transcriptional elongation. The deduced human protein contains 433 amino acid and shares 44% identity with the yeast protein in the first 230 amino acids. In contrast, the C-terminal regions of human and yeast NOT4 are much less conserved. Within the highly conserved N-terminal domain are 2 putative zinc fingers of the C2C2 type and an RNA recognition motif. Human NOT4 contains a putative C-terminal bipartite nuclear localization signal, and several potential phosphorylation sites are located proximal to this.