CCR4 NOT Transcription Complex Subunit 7 (CNOT7)

CNOT7 binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms. The authors identified cDNAs encoding human, C. elegans, and Arabidopsis homologs of mouse Caf1 and determined that mouse Caf1 is a homolog of yeast CAF1, which is required for expression of several genes. Yeast CAF1 was originally isolated as a mutant that was defective in glucose derepression of gene expression and exhibited temperature-sensitive growth.