CCR4 NOT Transcription Complex Subunit 8 (CNOT8)

The deduced 293-amino acid human homolog of yeast CAF1 shares 75% amino acid sequence identity with human CAF1. Comparative analysis of the protein sequences of human CALIF, human CAF1, and yeast CAF1 revealed 34% overall identity between CALIF and yeast CAF1 and 35% identity between human CAF1 and yeast CAF1.It cannot be determined from these numbers alone whether CALIF or human CAF1 is the true human ortholog of yeast CAF1. Both CALIF and human CAF1 are shorter than yeast CAF1, which contains an N-terminal extension of approximately 140 amino acids. CALIF can interact with yeast NOT1, an N-terminally truncated human NOT1 protein , human NOT3, and yeast CCR4.