CDGSH Iron Sulfur Domain Protein 1 (CISD1)

CISD1 is a member of the CDGSH domain-containing family and may play a role in the regulation of mitochondrial oxidative capacity. The deduced 108-amino acid protein has a calculated molecular mass of 12.2 kD and contains an N-terminal signal sequence and a C-terminal CDGSH domain, flanked by 2 additional cysteines. The CDGSH domain contains a consensus sequence shared by CISD1, CISD2, and CISD3 . Immunofluorescence studies localized CISD1 to the mitochondria. RT-PCR analysis of mouse tissues detected ubiquitous expression with highest expression in heart. Immunohistochemical staining of mouse tissues detected Cisd1 in many tissues, including liver, adipose tissue, skeletal muscle, and heart. Staining was particularly intense in cells lining the ducts and ventricles.