COMM Domain Containing Protein 5 (COMMD5)

Hcarg has a 67% alpha helix content, a calcium-binding EF-hand motif, 4 putative leucine zipper motifs, a nuclear receptor-binding domain, and no transmembrane domain. It also contains several putative phosphorylation sites and an N-glycosylation site. The deduced 224-amino acid protein shares 80% homology with rat Hcarg. Multiple-tissue expression array analysis detected high expression in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver. In situ hybridization of rat tissues detected expression in the medulla and zona fasciculata of the adrenal cortex and in the tubules of the kidney, but showed no expression in renal glomeruli.