CTTNBP2 N-Terminal Like Protein (CTTNBP2NL)

N terminus of CTTNBP2 is 38% identical and 53% similar to CTTNBP2NL over 649 aa. This N-terminal portion is predicted to contain a ~200-aa stretch of coiled-coil motifs. The PP2A phosphatase functions to dephosphorylate specific proteins originally targeted by stimulus-activated protein kinases. The identification of a sub-network surrounding the human PP2A-Striatin holoenzyme, termed STRIPAK, provides insight into novel mechanisms for PP2A function and regulation. STRIPAK participates in at least two mutually-exclusive sub-complexes, one of which contains the putative cortactin-binding protein, CTTNBP2NL. CTTNBP2NL is enriched at the actin cytoskeleton, likely in a STRIPAK-independent manner. STRIPAK interacts with a subunit of the dynein motor, at least partially, through CTTNBP2NL.