CUB And Sushi Multiple Domains Protein 2 (CSMD2)

The CSMD2 transcript contains an Alu repeat in the 3-prime untranslated region. RT-PCR detected intermediate expression in fetal brain, adult brain, spinal cord, and all specific adult brain regions examined. Lower levels were detected in spleen, lung, and testis, and little to no expression was detected in the other tissues examined.The deduced 3,487-amino acid protein has a calculated molecular mass of about 380 kD. Like CSMD1, CSMD2 contains 14 alternating CUB and sushi domains, followed by 12 additional tandem sushi domains (CSMD1 has 14), a single transmembrane domain, and a short cytoplasmic tail that contains putative phosphorylation sites. Unlike CSMD1 and CSMD3, CSMD2 does not have a signal peptide.