CUB Domain Containing Protein 2 (CDCP2)

Maraganore et al. (2005) identified the CDCP2 gene, which they called LOC200008, within the PARK10 locus for late-onset Parkinson disease (PD) susceptibility on chromosome 1.Maraganore et al. (2005) stated that the CDCP2 protein is predicted to have oxidoreductase activity and is potentially involved in cholesterol biosynthesis and electron transport.Maraganore et al. (2005) mapped the CDCP2 gene to chromosome 1p32.By examining CDCP2 SNPs in an expanded PD family dataset (293 multiplex and 467 singleton families) and a discordant sib-pair dataset, Li et al. (2007) found no significant association of CDCP2 with PD. They noted that the results confirmed previous negative findings for CDCP2 as a candidate PARK10 gene.