Calcium Binding Protein 5 (CABP5)

Calcium Binding Protein 5 belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown.The deduced 192-amino acid protein contains only 2 putative functional EF-hands, which correspond to EF-hands 3 and 4 of calmodulin. Northern blot analysis of multiple human tissues using a probe that does not distinguish between CABP3 and CABP5 showed no expression. However, expression of a 1.9-kb transcript was detected in bovine retina.