Calcium Channel, Voltage Dependent, Gamma Subunit 8 (CACNg8)

CACNg8 represents one of the gamma subunits. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is located in a cluster with two similar gamma subunit-encoding genes on chromosome 19. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. The deduced 414-amino acid CACNG8 protein contains 4 transmembrane segments, a highly conserved N-glycosylation site in the first extracellular loop, and, in its C terminus, conserved phosphorylation sites and a consensus target for binding by PDZ domain proteins.CACNG8 gene, like CACNG6 and CACNG7, contains 4 exons. Exon 4 in CACNG8 is relatively long and GC rich compared with that of its nearest homolog, CACNG4.