Calpain 15 (CAPN15)

The Drosophila small optic lobes (sol) gene encodes a protein with zinc finger-like repeats, a calpain -like protease domain, and a C-terminal region of unknown function. The predicted 1,086-amino acid protein shares 44% sequence identity with sol. The calpain-like domain and C-terminal region are highly conserved between SOLH and sol, and similar zinc fingers are present in the N-terminal regions of these proteins.The SOLH gene contains at least 14 exons distributed over more than 45 kb. Southern blot analysis indicated that SOLH is a single-copy gene. Using Northern blots, the authors demonstrated that SOLH is expressed as an approximately 5-kb mRNA in various human tissues; additional smaller transcripts were observed in some tissues.