Casitas B Lineage Lymphoma Proto-oncogene B (CBLB)

CBLB cDNA encodes a predicted 982-amino acid protein. Like CBL, CBLB contains putative nuclear localization signal, zinc finger, leucine zipper, and proline-rich domains. RT-PCR analysis indicated that there are leucine zipper-negative alternatively spliced forms of CBLB detectable in breast cancer cell lines.CBLB associates with FYN, FGR, and PLCG1 but not with the SH3 proteins NCK1, SPTA1, or EPS8.phosphorylation mediated by CD3Z, ZAP70, and LCK tyrosine kinases or by MAP kinases is not impaired by lack of CBLB. CBLB-deficient mice were also much more susceptible to experimental autoimmune encephalomyelitis, a model for multiple sclerosis, after immunization with myelin basic protein.