Caspase Activity And Apoptosis Inhibitor 1 (CAAP1)

The predominantly eukaryotic proteins typified by C8orf82. The relationship with the prokaryotic 2re3 type proteins. Definitely reproducible using profile-profile comparisons. There are some potentially difficult to account for deletions of strands between the two structures that makes it likely that the C8orf82 group has possibly only one PH-like domain. Further, one thing which becomes clear is that the C8orf82 is likely to be an enzyme with an active site formed by a cysteine, glutmate and histidine. Such a triad is very reminiscent of a peptidase/esterase like function. In conclusion while a single PH-like fold is conceivable for C8orf82 it is unlikely to have a function or quaternary structure like that proposed for the 2re3 group.