Cell Division Cycle Associated Protein 7 Like Protein (CDCA7L)

CDCA7L associated with chromatin, nuclear, and cytoplasmic fractions prepared from human embryonic kidney cells during log-phase growth. Northern blot analysis of murine tissues detected highest Cdca7l expression in prostate, thyroid, thymus, and salivary gland; no expression was detected in total brain.The N-terminal half of CDCA7L has an acidic domain followed by a PEST sequence, and the C-terminal half has a nuclear targeting sequence and a DNA-binding domain. The DNA-binding domain contains 12 conserved cysteines, 8 of which form 4 CxxC zinc finger motifs. CDCA7L also has several putative phosphorylation sites. Northern blot analysis detected a 3.0-kb CDCA7L transcript in whole human brain and in all peripheral tissues and human cell lines examined.