Cellular Nucleic Acid Binding Protein (CNBP)

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2.Cholesterol homeostasis is maintained in part by negative feedback regulation of the genes for proteins involved in cholesterol synthesis and the cellular uptake of cholesterol. The apparent coordinate regulation of several such genes, including HMG-CoA reductase, HMG-CoA synthase, farnesylpyrophosphate synthetase, and the LDL receptor suggest that these genes may be regulated by a common trans-acting factor that is able to """sense""" the levels of cellular sterols. In common with the viral NBPs, CNBP appeared to have a strong preference for single-stranded DNA.